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113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR)

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113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR)

Auteurs : RBID : ISTEX:259_1978_Article_BF00256640.pdf

Abstract

For measurement of glomerular filtration rate the usefulness of diethyl triamino penta acic (DTPA) labelled with 113mIndium has been explored.The labelling procedure is very simple, since eluate from an 113mIn generator can be used directly for labelling DTPA.The in vitro and in vivo binding of 113mIn to DTPA in competition with serum proteins was studied by gel-filtration. The radioactivity within the 113mIn-DTPA peak represented 100.6, 107.1 and 99.6% of the amount of radioactivity applied to the gel column for the in vivo studies, and 102.0 and 101.4% for the in vitro studies.Furthermore, the clearance of 113mIn-DTPA was compared to the clearance of 125I-iothalamate using the constant infusion technique. The clearance values were found to be nearly equal (r=0.996).It is concluded that 113mIn is almost entirely bound to DTPA after intravenous injection of the 113mIn-DTPA complex, and that the complex is a suitable agent for determination of glomerular filtration rate.

DOI: 10.1007/BF00256640

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<author><name>R. S. Johansson</name>
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<author><name>D. K. Falch</name>
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<front><div type="abstract" xml:lang="eng">For measurement of glomerular filtration rate the usefulness of diethyl triamino penta acic (DTPA) labelled with 113mIndium has been explored.The labelling procedure is very simple, since eluate from an 113mIn generator can be used directly for labelling DTPA.The in vitro and in vivo binding of 113mIn to DTPA in competition with serum proteins was studied by gel-filtration. The radioactivity within the 113mIn-DTPA peak represented 100.6, 107.1 and 99.6% of the amount of radioactivity applied to the gel column for the in vivo studies, and 102.0 and 101.4% for the in vitro studies.Furthermore, the clearance of 113mIn-DTPA was compared to the clearance of 125I-iothalamate using the constant infusion technique. The clearance values were found to be nearly equal (r=0.996).It is concluded that 113mIn is almost entirely bound to DTPA after intravenous injection of the 113mIn-DTPA complex, and that the complex is a suitable agent for determination of glomerular filtration rate.</div>
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<abstract lang="eng">For measurement of glomerular filtration rate the usefulness of diethyl triamino penta acic (DTPA) labelled with 113mIndium has been explored.The labelling procedure is very simple, since eluate from an 113mIn generator can be used directly for labelling DTPA.The in vitro and in vivo binding of 113mIn to DTPA in competition with serum proteins was studied by gel-filtration. The radioactivity within the 113mIn-DTPA peak represented 100.6, 107.1 and 99.6% of the amount of radioactivity applied to the gel column for the in vivo studies, and 102.0 and 101.4% for the in vitro studies.Furthermore, the clearance of 113mIn-DTPA was compared to the clearance of 125I-iothalamate using the constant infusion technique. The clearance values were found to be nearly equal (r=0.996).It is concluded that 113mIn is almost entirely bound to DTPA after intravenous injection of the 113mIn-DTPA complex, and that the complex is a suitable agent for determination of glomerular filtration rate.</abstract>
<relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title>
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<titleInfo><title>European Journal of Nuclear Medicine</title>
<partNumber>Year: 1978</partNumber>
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113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR)

113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR)

Abstract

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Le document en format XML

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Pour mettre un lien sur cette page dans le réseau Wicri